Influence of dietary vitamin E on the lungs of ozone-exposed rats
The effect of dietary vitamin E on pulmonary susceptibility to near ambient levels of ozone was studied in rats. Exposure to 0.7 or 0.8 ppM ozone continuously for 7 days resulted in significant biochemical augmentations in the lungs of both vitamin E-deficient and -supplemented rats. The relative order of the change was glutathione (GSH) peroxidase > lactate dehydrogenase > glucose-6-phosphate (G-6-P) dehydrogenase and pyruvate kinase > reduced glutathione > malic enzyme > glutathione reductase > protein and malic dehydrogenase. Except for malic dehydrogenase, the degrees of biochemical changes were greater in the lungs of vitamin E-deficient rats than those of the supplemented group following ozone exposure, and the differences in the levels of GSH peroxidase, G-6-P dehydrogenase, pyruvate kinase, and GSH were statisically significant. Histological examination of animal lungs revealed that all aminals exposed to 0.7 ppM ozone for 7 days had detectable lesions compared to none from the control groups. However, almost all the lungs categorized as having severe lesions by two investigators in a blind study were from rats fed the vitamin E-deficient diet, while nearly all the lungs from the supplemented group had mild lesions. The results suggest that dietary vitamin E alters cellular sensitivity of lung tissue to ozone exposure, and that depletion of dietary vitamin E lowers the threshold concentration of ozone at which effects can be detected.
- Research Organization:
- Univ. of Kentucky, Lexington
- OSTI ID:
- 5566176
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 20:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500 -- Metabolism
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
INFORMATION
ISOLATED VALUES
KINETICS
LUNGS
MAMMALS
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
ORGANS
OZONE
RATS
REACTION KINETICS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
TOLERANCE
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS