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Long-term NO/sub 2/ exposure of mice in the presence and absence of vitamin E. II. Effect of glutathione peroxidase

Journal Article · · Arch. Environ. Health; (United States)
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One hundred and twenty female mice fed diets containing various levels of vitamin E were continuously exposed to 0.5 ppM, 1.0 ppM nitrogen dioxide (NO/sub 2/), and filtered air for 17 months. Blood, lung, and liver tissues were assayed for glutathione peroxidase (GSH-peroxidase) activity. Exposure to 0.5 ppM NO/sub 2/ did not affect blood and lung GSH-peroxidase activity; 1.0 ppM NO/sub 2/ exposure however, caused suppression of the enzyme. A combination of vitamin E deficiency and 1.0 ppM NO/sub 2/ exposure resulted in the lowest GSH-peroxidase activities in the blood and lung. High levels of vitamin E in the diet resulted in elevated GSH-peroxidase in the blood and lung. Liver GSH-peroxidase activity was unaffected by either dietary vitamin E or NO/sub 2/ exposure.
OSTI ID:
6110474
Journal Information:
Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 33:6; ISSN AEHLA
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHALCOGENIDES
CHEMISTRY
CHRONIC EXPOSURE
DIGESTIVE SYSTEM
DRUGS
ENZYME ACTIVITY
ENZYMES
FEMALES
GLANDS
GLUTATHIONE
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LIVER
LUNGS
MAMMALS
MATERIALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEPTIDES
PEROXIDASES
POLYPEPTIDES
PORPHYRINS
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
VITAMIN E
VITAMINS