Osteosarcoma development following single inhalation exposure to americium-241 in beagle dogs

Journal Article · Tue Oct 01 00:00:00 EDT 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576780· OSTI ID:6286342

Gillett, N A; Hahn, F F; Mewhinney, J A; Muggenberg, B A

Young, mature Beagle dogs underwent single inhalation exposure to respirable aerosols of SU AmO2 to determine the radiation dose distribution to tissues. The dogs were serially sacrificed to assess the clearance of SU Am from the lung, the rate of translocation to internal organs, the pattern of retention in the organs, and the rates and modes of excretion. Americium dioxide was relatively soluble in the lung, leading to the translocation of significant quantities of SU Am to bone and liver, thus delivering radiation doses to these tissues nearly equal to that received by the lung. Osteoblastic osteosarcomas developed in four dogs surviving more than 1000 days after exposure. Histologically, all of the osteosarcomas were associated with areas of radiation osteodystrophy characterized by bone infarction, peritrabecular new bone formation, marrow fibrosis, and microresorptive cavities. The retention and translocation of inhaled SU Am in dogs is similar to that of man, indicating that 241Am inhaled by humans may potentially result in significant risk of bone tumor development.

• Research Organization: Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM
• OSTI ID: 6286342
• Journal Information: Radiat. Res.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMERICIUM 241
INHALATION
AMERICIUM OXIDES
OSTEOSARCOMAS
RADIOINDUCTION
SKELETON
DELAYED RADIATION EFFECTS
BEAGLES
ENVIRONMENTAL EXPOSURE
LIVER
LUNG CLEARANCE
RADIOACTIVE AEROSOLS
RADIONUCLIDE KINETICS
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALPHA DECAY RADIOISOTOPES
AMERICIUM COMPOUNDS
AMERICIUM ISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHALCOGENIDES
CLEARANCE
COLLOIDS
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
DOGS
EXCRETION
GLANDS
HEAVY NUCLEI
INTAKE
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIOISOTOPES
SARCOMAS
SKELETAL DISEASES
SOLS
TRANSPLUTONIUM COMPOUNDS
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals