Primary bone neoplasms in beagle dogs exposed by inhalation to aerosols of plutonium-238 dioxide

Journal Article · Thu Oct 01 04:00:00 EDT 1981 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5173258

Hahn, F F; Mewhinneyk, J A; Merickel, B S; Guilmette, R A; Boecker, B B; McClellan, R D

Primary bone neoplasms developed in beagle dogs briefly exposed by inhalation to aerosols of /sup 238/PuO/sub 2/. /sup 238/PuO/sub 2/ was initially deposited in the respiratory tract where it was retained with a half time greater than 100 days. A portion of the /sup 238/Pu was solubilized and translocated to the liver and skeleton. Five years after exposure, 46 osteosarcomas developed in 35 of 144 exposed dogs. The cumulative absorbed radiation doses to skeleton for these dogs ranged from 210 to 830 rad. Of the 46 bone tumors, 22 originated in the vertebrae, 12 in the humeri, 6 in the pelves, and 6 in miscellaneous long and flat bones. Most of the tumors were well-differentiated sarcomas. Only 10 of the tumors metastasized; the lung was the organ most often invaded. Bone tumors were associated with lesions of radiation osteodysplasia. The number of bone tumors found in this study indicated that inhaled /sup 238/PuO/sub 2/ was an effective skeletal carcinogen. The rate of solubilization in the lung and translocation to bone may be a factor in the radiation dose pattern and type and location of bone tumors that developed after inhalation of /sup 238/PuO/sub 2/.

• Research Organization: Environmental Research Inst., Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5173258
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 67:4; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENS
CHALCOGENIDES
COLLOIDS
DISEASES
DISPERSIONS
DOGS
DOSES
EVEN-EVEN NUCLEI
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNGS
MAMMALS
NEOPLASMS
NESDPS Office of Nuclear Energy Space and Defense Power Systems
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM 238
PLUTONIUM COMPOUNDS
PLUTONIUM DIOXIDE
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
SKELETON
SOLS
TRANSLOCATION
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES