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Comparison of Bone Lesions by Inhaled 90Sr Cl2 or 238PuO2

Conference ·
OSTI ID:5318269
 [1];  [1];  [1];  [1];  [1]
  1. Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
+ Show Author Affiliations
Radionuclides inhaled in a soluble form translocate from the lung to other organs of the body. A frequent site of deposition and retention is the skeleton. If the dose delivered to the skeleton is high enough, bone tumors may result. Both 90Sr Cl2 and 238PuO2 are radionuclides that have induced bone neoplasms in Beagle dogs after inhalation exposure. In this paper, we compare and contrast the bone tumors induced by these two radionuclides that have emissions with widely different energy linear energy transfer characteristics.
Research Organization:
Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
DOE Contract Number:
AC04-76EV01013
OSTI ID:
5318269
Report Number(s):
CONF-9107167--1; ON: DE91017509
Country of Publication:
United States
Language:
English

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Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL HALF-LIFE
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CARCINOGENESIS
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
CONNECTIVE TISSUE
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOGS
DOSE-RESPONSE RELATIONSHIPS
EVEN-EVEN NUCLEI
EXPERIMENTAL NEOPLASMS
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEAVY ION DECAY RADIOISOTOPES
HEAVY NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIVER
LUNGS
MAMMALS
NEOPLASMS
NUCLEI
ORGANS
OSTEOSARCOMAS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PLUTONIUM 238
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
SARCOMAS
SILICON 32 DECAY RADIOISOTOPES
SKELETAL DISEASES
SKELETON
SPATIAL DISTRIBUTION
SPONTANEOUS FISSION RADIOISOTOPES
STRONTIUM 90
STRONTIUM CHLORIDES
STRONTIUM COMPOUNDS
STRONTIUM ISOTOPES
TISSUE DISTRIBUTION
TISSUES
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOT
YEARS LIVING RADIOISOTOPES