Single inhalation exposure to /sup 90/SrCl/sub 2/ in the beagle dog: late biological effects

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6020868

Gillett, N A; Muggenburg, B A; Boecker, B B; Griffith, W C; Hahn, F F; McClellan, R O

Late-occurring biologic effects were studied in beagle dogs that were given graded levels of /sup 90/SrCl/sub 2/ via single brief inhalation exposures and were subsequently observed for their life-span. Due to the soluble chemical form of the aerosol, /sup 90/Sr was rapidly translocated from lung and deposited in bone where it was subsequently retained for a long period of time. Radiation-induced lesions were confined to the bone, bone marrow, and adjacent soft tissue. Forty-five primary bone tumors occurred in 31 of 66 exposed dogs. Metastasis occurred from 21 tumors, with the lung being the most frequent site of metastasis (76%). Twenty-seven tumors were classified as different subtypes of osteosarcoma, 14 as hemangiosarcomas, 3 as fibrosarcomas, and 1 as a myxosarcoma. Four carcinomas arising from soft tissues adjacent to bone were also considered to be /sup 90/Sr induced. In contrast to bone tumors arising in beagles chronically exposed to 90Sr through ingestion, histologic lesions of radiation osteodystrophy were minimal in this study, indicating that these lesions are not a necessary precursor of osteosarcoma development. The incidences of hemangiosarcomas (31%) and telangiectatic osteosarcomas (11%) in addition to osteosarcomas suggest that the cell of origin for all of these neoplasms is a multipotent mesenchymal cell with the potential for various morphologic expressions dependent on local environmental factors.

• Research Organization: Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM
• OSTI ID: 6020868
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 79:2; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AEROSOLS
ALKALINE EARTH ISOTOPES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY BURDEN
CARCINOGENESIS
COLLOIDS
DISEASES
DISPERSIONS
DOGS
EVEN-EVEN NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIFE SPAN
LUNGS
MAMMALS
METASTASES
NEOPLASMS
NUCLEI
ORGANS
PATHOGENESIS
RADIOACTIVE AEROSOLS
RADIOINDUCTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
SKELETON
SOLS
STRONTIUM 90
STRONTIUM ISOTOPES
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES