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Effects of simultaneous radiofrequency radiation and chemical exposure of mammalian cells. Volume 2. Final report, 2 January 1984-31 December 1986

Technical Report ·
OSTI ID:6277091
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A circulating water-bath exposure system was designed for in vitro radio-frequency radiation (RFR) exposure studies in the 915- to 2450-MHz range. A continuously rotating styrofoam float, holding ten T-25 tissue-culture flasks, averages out field heterogeneity and allows mixing in the medium in the flasks. The presence of cells in the exposure flask (as attached monolayer or cell suspension) did not result in an SAR different from that measured in the medium without cells present. Two hypotheses are posed relative to the mutagenic activity of RFR: (a) that RFR by itself is genotoxic to mammalian cells in vitro; and (b) that a simultaneous exposure of mammalian cells to RFR during treatment with a genotoxic chemical will result in an alteration of the genotoxic activity of the chemical alone. RFR exposure alone (at moderate power levels which resulted in a temperature increase in the cell-culture medium of no more than 3 C) is not mutagenic. During simultaneous treatment, the RFR does not affect either the inhibition of cell growth or the extent of mutagenesis resulting from the chemical treatment alone. The same two hypotheses were explored for induction of sister chromatid exchanges (SCEs) and chromosome aberrations in Chinese hamster ovary cells which were similarly exposed to RFR and chemicals. The chemicals studied for SCE induction were mitomycin C (MMC) and Adriamycin.
Research Organization:
Texas Univ., San Antonio (USA). Health Science Center
OSTI ID:
6277091
Report Number(s):
AD-A-202780/3/XAB
Country of Publication:
United States
Language:
English

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Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMICAL REACTIONS
CHROMATIN
CHROMOSOMES
CULTURE MEDIA
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
GONADS
HAMSTERS
INHIBITION
LAYERS
MAMMALS
MICROWAVE RADIATION
MUTAGENS
MUTATIONS
ORGANS
OVARIES
PROGRESS REPORT
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES