Absence of mutagenic interaction between microwaves and mitomycin C in mammalian cells

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Environmental and Molecular Mutagenesis; (USA)

DOI:https://doi.org/10.1002/em.2850130404· OSTI ID:7004314

Meltz, M L; Eagan, P ^[1]; Erwin, D N ^[2]

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1. Univ. of Texas, Austin (USA)
2. USAF School of Aerospace Medicine, San Antonio, TX (USA)

Evidence in the literature from in vitro and in vivo studies as to whether or not radiofrequency radiation (RFR) in the microwave range is mutagenic is predominantly negative, with some positive reports. No evidence is available as to whether FRF will alter the mutagenic activity of genotoxic chemicals during a simultaneous exposure, a likely real-life situation. Two hypotheses have been proposed: (a) that RFR by itself can cause mutations in a mammalian cell in vitro assay system; and (b) that a simultaneous exposure to RFR during a chemical treatment of the cells with a known genotoxic agent, mitomycin C (MMC), will alter the extent of mutagenesis induced by the treatment of the cells by the chemical alone. These studies were preformed using the forward mutation assay at the thymidine kinase locus in L518Y mouse leukemic cells. The pulsed wave RFR was broadcast from an antenna horn at a frequency of 2.45 GHz. The conclusions from five different experiments, employing three different concentrations of MMC, were that (a) RFR exposure alone, at moderate power levels which resulted in a temperature increase in the cell culture medium of less than 3{degree}C, is not mutagenic; and (b) when cells are simultaneously treated with MMC and RFR at these same moderate power levels, the RFR does not affect either the inhibition of cell growth or the extent of mutagenesis resulting from the treatment with the chemical MMC alone.

• OSTI ID: 7004314
• Journal Information: Environmental and Molecular Mutagenesis; (USA), Journal Name: Environmental and Molecular Mutagenesis; (USA) Vol. 13:4; ISSN 0893-6692; ISSN EMMUE
• Country of Publication: United States
• Language: English

Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
IMMUNE SYSTEM DISEASES
LEUKEMIA
MAMMALS
MICE
MICROWAVE RADIATION
MITOMYCIN
MUTAGENESIS
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PYRIMIDINES
RADIATIONS
RADIOWAVE RADIATION
RIBOSIDES
RODENTS
SYNERGISM
THYMIDINE
TRANSFERASES
TUMOR CELLS
VERTEBRATES