Arterial blood gases, pulmonary function and pathology in rats exposed to 0. 75 or 1. 0 ppM ozone

Journal Article · Sun Jun 01 04:00:00 EDT 1980 · J. Environ. Pathol. Toxicol.; (United States)

OSTI ID:6269824

Pepelko, W E; Mattox, J K; Yang, Y Y

Arterial blood gases, residual lung volume (RV), deflation pressure volume (PV) curves, pulmonary pathology and body weight changes were studied in rats exposed up to 14 days to either 0.75 or 1.0 ppM ozone. Arterial PO2 and body weights decreased progressively with length of exposure while PaCO2 and RV increased. The slope of the PV curve decreased in all groups exposed to ozone. Pathological changes in the lung increased in severity with concentration and length of exposure. The present findings have shown that arterial blood gas measurements represent a sensitive index of altered lung function in rats, a species very sensitive to ozone exposure.

• OSTI ID: 6269824
• Journal Information: J. Environ. Pathol. Toxicol.; (United States), Journal Name: J. Environ. Pathol. Toxicol.; (United States) Vol. 3:5-6; ISSN JEPTD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
DOSE-RESPONSE RELATIONSHIPS
FUNCTIONS
GAS ANALYSIS
LUNGS
MAMMALS
MATERIALS
ORGANS
OZONE
PATHOLOGICAL CHANGES
RATS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
VOLUME
WEIGHT