Effect of 0. 64 ppm ozone on rats with chronic pulmonary bacterial infection

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530549· OSTI ID:5994882

Sherwood, R L; Kimura, A; Donovan, R; Goldstein, E

Rats were chronically infected with Pseudomonas aeruginosa by entrapping viable bacteria in agar beads and intratracheally inoculating the beads into the left lung. The infection was allowed to stabilize over a 10-d period and the animals were then placed in environmental chambers and exposed to either filtered air or 0.64 ppm ozone (23 h/d) for 14 or 28 d. Rats exposed to ozone had reduced body weight and increased lung sizes and lung weights compared with animals breathing filtered air. Rats inoculated with beads containing live P. aeruginosa had increased lung weights when compared with rats inoculated with beads containing heat-killed P. aeruginosa or controls. Quantitation of total viable bacteria in rats exposed to ozone or to filtered air revealed no significant differences in bacterial numbers. Thus, in this model, chronic exposure to ozone produces increases in lung volume and weight but does not enhance a smoldering Pseudomonas infection. 28 references, 1 figure, 2 tables.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5994882
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 13:4-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ATMOSPHERES
BACTERIA
BODY
CONTROLLED ATMOSPHERES
DATA
DISEASE RESISTANCE
EXPERIMENTAL DATA
INFORMATION
LUNGS
MAMMALS
MICROORGANISMS
NUMERICAL DATA
ORGANS
OZONE
PSEUDOMONAS
RATS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES
VOLUME
WEIGHT