Effects of 28 days exposure to diesel engine emissions in rats
Journal Article
·
· Environ. Res.; (United States)
Groups of 15 rats each were exposed 20 hr/day, 7 days/week for 28 days to a 1:14 dilution of either raw or irradiated exhaust using a six-cylinder Nissan diesel engine. Body weight gains were significantly (p < 0.05) reduced during exposure to diesel exhaust with a greater decrease during exposure to irradiated compared with raw exhaust. Arterial blood gases and standard bicarbonate remained unchanged. Arterial blood pH was slightly but significantly (p < 0.05) decreased in the animals previously exposed to irradiated exhaust. Residual volume (RV) and wet lung weight were unchanged after exposure to either condition, while vital capacity (VC) and total lung capacity (TLC) were increased (p < 0.05) following exposure to raw exhaust. The shape of the deflation PV curves were nearly identical among the three groups. It was concluded that 28 days exposure to a 1:14 dilution of diesel exhaust emissions resulted in only minor functional changes in the lungs.
- Research Organization:
- Environmental Protection Agency, Cincinnati, OH
- OSTI ID:
- 5657292
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 27:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
DIESEL ENGINES
ENGINES
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
HEAT ENGINES
INTERNAL COMBUSTION ENGINES
LUNGS
MAMMALS
MATERIALS
ORGANS
PH VALUE
PHYSIOLOGY
RADIATION EFFECTS
RATS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
DIESEL ENGINES
ENGINES
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
HEAT ENGINES
INTERNAL COMBUSTION ENGINES
LUNGS
MAMMALS
MATERIALS
ORGANS
PH VALUE
PHYSIOLOGY
RADIATION EFFECTS
RATS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
WASTES