Pulmonary function and pathology in cats exposed 28 days to diesel exhaust

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · J. Environ. Pathol. Toxicol.; (United States)

OSTI ID:6054234

Pepelko, W E; Mattox, J K; Yang, Y Y; Moore, W Jr

Young adult male cats were exposed 28 days, 20 hrs per day, to a 1:14 dilution of diesel exhaust emissions. Following termination of exposure, the following pulmonary function measurements were carried out: lung volumes, maximum expiratory flow rates (MEF), MEF at 50%, 25% and 10% of vital capacity (VC): forced expiratory volume (FEV) after 0.2, 0.3 and 0.4 sec, dynamic compliance, resistance and helium washout at 25, 50, 75, and 100 breaths per min. The only significant functional change was a decrease in MEF at 10% of VC (P x .02). The lungs of the exposed cats appeared charcoal grey with frequent focal black spots visible on the pleural surface. Pathologic changes in the exposed cats included a predominantly peribronchiolar localization of black-pigmented macrophages within the alveoli producing a focal pneumonitis or alveolitis. In general, evidence of serious lung damage was not observed following the 28-day exposure period.

• OSTI ID: 6054234
• Journal Information: J. Environ. Pathol. Toxicol.; (United States), Journal Name: J. Environ. Pathol. Toxicol.; (United States) Vol. 4:2-3; ISSN JEPTD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AUTOMOBILES
BIOLOGICAL EFFECTS
BODY
CATS
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
DIESEL ENGINES
ENGINES
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
HEAT ENGINES
INTERNAL COMBUSTION ENGINES
LUNGS
MACROPHAGES
MAMMALS
ORGANS
PATHOLOGICAL CHANGES
PHAGOCYTES
PHYSIOLOGY
PNEUMONITIS
RESPIRATORY SYSTEM
SOMATIC CELLS
VEHICLES
VERTEBRATES
WASTES