In vitro generation of nonspecific suppressor cells and their characterization. [X radiation]
Journal Article
·
· Transplantation; (United States)
OSTI ID:6252610
In vitro preculture of C3H/He splenocytes for 48 to 96 hr induces aspecific suppressor cells evaluated by their ability to reduce /sup 3/H-TdR uptake by fresh syngeneic splenocytes stimulated by different amounts of Concanavalin A (Con A) in vitro. This suppressive activity is obtained in medium containing 10% heat-inactivated fetal calf serum (FCS) or similar amounts of heat-inactivated bovine serum, syngeneic, or allogeneic murine sera but not by unheated FCS. Suppressive activity is resistant to mitomycin C and radiation up to 5,000 R. Exposure of precultured cells to carbonyl iron or plastic adherence, but not to anti-Thy 1.2 serum plus complement, results in removal of the suppressive activity.
- Research Organization:
- Istituto di Ricerche Farmacologiche, Milan, Italy
- OSTI ID:
- 6252610
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 27:5; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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Further characterization of suppressor lymphocytes induced by fetal calf serum in murine lymphoid cell cultures: comparison with in vitro-generated cytotoxic lymphocytes. [X Radiation]
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Comparison of the suppressor cells found in the spleens of 89Sr-treated mice and in normal murine bone marrow
Journal Article
·
Wed Mar 14 23:00:00 EST 1979
· Cell. Immunol.; (United States)
·
OSTI ID:6294829
Regulation of delayed-type hypersensitivity: VI. Antigen-specific suppressor T cells and suppressor factor for delayed-type hypersensitivity to histocompatibility antigens
Journal Article
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Thu Dec 31 23:00:00 EST 1981
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OSTI ID:6715928
Comparison of the suppressor cells found in the spleens of 89Sr-treated mice and in normal murine bone marrow
Journal Article
·
Sat Feb 28 23:00:00 EST 1981
· J. Immunol.; (United States)
·
OSTI ID:6025635
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIBIOTICS
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
CELL PROLIFERATION
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENERGY
EXPERIMENTAL DATA
GLOBULINS
GRAPHS
HEAT
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IMMUNE REACTIONS
IMMUNE SERUMS
IN VITRO
INACTIVATION
INFORMATION
IONIZING RADIATIONS
IRON
ISOLATED VALUES
ISOTOPES
LIGHT NUCLEI
METALS
MITOMYCIN
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RIBOSIDES
SOMATIC CELLS
SPLEEN CELLS
THYMIDINE
TRANSITION ELEMENTS
TRITIUM
X RADIATION
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIBIOTICS
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
CELL PROLIFERATION
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENERGY
EXPERIMENTAL DATA
GLOBULINS
GRAPHS
HEAT
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IMMUNE REACTIONS
IMMUNE SERUMS
IN VITRO
INACTIVATION
INFORMATION
IONIZING RADIATIONS
IRON
ISOLATED VALUES
ISOTOPES
LIGHT NUCLEI
METALS
MITOMYCIN
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RIBOSIDES
SOMATIC CELLS
SPLEEN CELLS
THYMIDINE
TRANSITION ELEMENTS
TRITIUM
X RADIATION
YEARS LIVING RADIOISOTOPES