Mechanical properties of rabbit lung with edema caused by exposure to ozone

Journal Article · Sat Dec 31 23:00:00 EST 1988 · J. Environ. Pathol., Toxicol. Oncol.; (United States)

OSTI ID:6251994

Yokoyama, E; Goto, H; Kawai, K; Kyono, H

Rabbits were intermittently exposed to ozone (O/sub 3/) and the mechanical properties of their lungs were studied in order to know details of ventilatory functions in lung injuries caused by this gas. The lungs of rabbits exposed to 2 ppm O/sub 3/ for 6 hours daily for 3 days showed the earlier stage of edema, and tended to trap air as distending pressure was lowered at the measurement of volume-pressure relationship. In this group of animals, dynamic compliance decreased, pulmonary flow resistance increased, and flow-volume curve obtained by forced deflation showed a definitely altered slope with reduced flows at the latter part of descending limb. On the other hand, the significant change observed in rabbits exposed to 1 ppm O/sub 3/ for 6 hours daily for 7 days was only the increase in pulmonary flow resistance: the extent was similar to that observed in the former group of rabbits. Light-microscopical study for the airways of O/sub 3/-exposed rabbits revealed varying degrees of epithelial damages and submucosal edema in the large airways and in terminal and respiratory bronchioles, and thickening of alveolar walls in the proximal alveolar ducts, being much more evident in the former group.

• Research Organization: Institute of Public of Health, Tokyo (Japan)
• OSTI ID: 6251994
• Journal Information: J. Environ. Pathol., Toxicol. Oncol.; (United States), Journal Name: J. Environ. Pathol., Toxicol. Oncol.; (United States) Vol. 9:1; ISSN JEPOE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL TISSUES
ANIMALS
BODY
DYNAMIC FUNCTION STUDIES
EDEMA
EPITHELIUM
LUNGS
MAMMALS
ORGANS
OZONE
PATHOLOGICAL CHANGES
POLLUTION
RABBITS
RESPIRATORY SYSTEM
SYMPTOMS
TISSUES
TOXICITY
VERTEBRATES