Respiratory effects of intermittent exposure to ozone of rats

Journal Article · Sun Apr 01 04:00:00 EST 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90024-0· OSTI ID:7012187

Yokoyama, E; Ichikawa, I; Nambu, Z; Kawai, K; Kyono, Y

Intermittent exposures of rats to ozone (O/sub 3/) of 1 and 0.5 ppm were performed. Flow resistance of the lungs left in situ in the chest cavity opened after the sacrifice was measured at different levels of elastic pressure, and it was shown that daily 3-hr exposures to 1 ppm O/sub 3/ for 30 consecutive days mainly produced increased resistance of more-central airways, while daily 6-hr exposures to 0.5 ppm O/sub 3/ for 60 consecutive days mainly increased the resistance of peripheral airways. Morphological changes of the lungs caused by both exposures were in general similar in nature, but differences in secretion were noticed: it was more evident in larger to middle-sized bronchi in the animals intermittently exposed to 1 ppm O/sub 3/, but more evident in the peripheral airway region in the animals intermittently exposed to 0.5 ppm O/sub 3/. No change in the pulmonary static volume-pressure curve, indicative of the altered retractive forces of alveoli, was observed in both exposures, although a slight reduction in lung distensibility was suggested.

• Research Organization: Inst. of Industrial Health, Kawasaki, Japan
• OSTI ID: 7012187
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 33:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
BRONCHI
DOSE-RESPONSE RELATIONSHIPS
EXPOSURE CHAMBERS
FUNCTIONS
LUNGS
MAMMALS
MORPHOLOGICAL CHANGES
ORGANS
OZONE
RATS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES