Stimulation of DNA synthesis in the lungs of hamsters exposed intermittently to nitrogen dioxide

Journal Article · Sun May 01 04:00:00 EDT 1977 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397709529515· OSTI ID:7211803

Creasia, D A; Nettesheim, P; Kim, J C.S.

Stimulation of (/sup 3/H) thymidine incorporation in the lungs of hamsters exposed singly and repeatedly to 10 ppM NO/sub 2/ was studied. Within 24 hr of the first exposure to NO/sub 2/, the response was characterized by a marked increase in (/sup 3/H) thymidine labeling in the bronchi, bronchioles, and alveolar ducts, but not in the trachea or the peripheral alveoli. If, after the first NO/sub 2/ exposure, subsequent exposures were repeated daily, no further stimulation of (/sup 3/H) thymidine incorporation was observed in any part of the respiratory tract. However, if the interval between the first and subsequent exposures was 2-3 days rather than 1 day, stimulation of (/sup 3/H) thymidine incorporation was observed in the bronchi, bronchioles, and alveolar ducts for up to 21 NO/sub 2/ exposures. A significantly greater increase in (/sup 3/H) thymidine incorporation was observed when the interval between subsequent exposures was extended to 7 days. However, no repeated exposure, whether at 2-3 or 7 day intervals, was as effective as the first NO/sub 2/ exposure in stimulating incorporation of vertical bar (/sup 3/H) vertical bar thymidine.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 7211803
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 2:5; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BRONCHI
CHALCOGENIDES
DNA
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
LUNGS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PYRIMIDINES
RADIOISOTOPES
RESPIRATORY SYSTEM
RIBOSIDES
RODENTS
STIMULATION
SYNTHESIS
THYMIDINE
TIME DEPENDENCE
TRACHEA
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES