Proliferation of lung and airway cells induced by nitrogen dioxide

Journal Article · Sat Sep 01 00:00:00 EDT 1979 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397909529801· OSTI ID:5791767

Hackett, N A

Proliferation of lung cells of Chinese hamsters was examined in several regions of the lung parenchyma and ciliated airway epithelium after a 24-h exposure to 28.2 mg/m/sup 3/ (15 ppM) nitrogen dioxide (NO/sub 2/). Label was retained 3 wk after the injection of (/sup 3/H)thymidine, and autoradiographic methods were used to localize the site of retention. By 24 h after administration of (/sup 3/H)thymidine, parenchymal areas, exclusive of airways, showed an increased labeling index, indicative of cell death and replacement. This increase in the number of labeled cells persisted for 3 wk. Type II cells were labeled twice as frequently in regions of the terminal bronchiole than in other alveolar areas. Type II cell cycle time was reduced from 26 to 3 d after NO/sub 2/ exposure. Alveolar macrophages were significantly labeled in the alveolar areas during the thymidine pulse at the end of the exposure episode and retained label for 3 wk. Airway epithelia showed no labeling in the trachea and progressively greater labeling in increasingly smaller airways. Epithelial cells lining the small airways and alveoli showed greater susceptibility to NO/sub 2/ injury than cells lining the bronchi or trachea. Nonciliated or basal cells serve as a precursor of ciliated cells in the epithelium of small airways (0.35 mm) and bronchi.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
• DOE Contract Number: EY-76-C-04-1013
• OSTI ID: 5791767
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 5:5; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
AUTORADIOGRAPHY
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CELL KILLING
CHALCOGENIDES
EPITHELIUM
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
LUNGS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PYRIMIDINES
RADIOISOTOPES
RESPIRATORY SYSTEM
RETENTION
RIBOSIDES
RODENTS
THYMIDINE
TISSUES
TRACHEA
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES