Physiologic changes in the lungs of rabbits continuously exposed to nitrogen dioxide

Journal Article · Sat Dec 31 23:00:00 EST 1966 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:7204774

Davidson, J T; Lillington, G A; Haydon, G B; Wasserman, K

Rabbits exposed to 25 ppM NO/sub 2/ died within 3 days. 50 to 60% of those exposed to 8 to 12 ppM NO/sub 2/ died of extensive pulmonary congestion, edema, and pneumonia within 12 wk. Those surviving 3 to 4 months exposure to 8 to 12 ppM NO/sub 2/ compared with controls; i.e., lower Pa/sub O/sub 2//, no change in Pa/sub CO/sub 2//, marked increase in mean of nonelastic resistance (mainly airway resistance), increase in functional residual capacity, and no significant change in static lung compliance. Changes reversed during the 28-day recovery. Widespread hyperplasia and inflammation in terminal bronchioles of exposed rabbits occurred. Irregular alveolar sacs and destruction of alveolar wall architecture were observed. There were obstructive changes due to bronchiolitis; i.e., persistent destructive changes associated with only minor functional changes and resembling emphysema.

• OSTI ID: 7204774
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 95; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
CHALCOGENIDES
DISEASES
EDEMA
EMPHYSEMA
LUNGS
MAMMALS
MORTALITY
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PATHOLOGY
RABBITS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SYMPTOMS
VERTEBRATES