Emphysema after low-level exposure to NO/sub 2/
Rats were exposed to various levels of NO/sub 2/ for their life-span. At a concentration of 100 ppM they began to die within 24 h from acute pulmonary edema. At 50 ppM, 6 of 9 rats died within 48 to 68 days, 2 were removed to control environment. At 25 ppM, rats sacrificed after 40 days appeared normal in weight but some had histopathologic lung changes (e.g., hyperplasia, hypertrophy). Ten of 15 died within 121 to 180 days, 1 died of other causes in 7 days, 1 was allowed to recover, 3 were sacrificed. Low body weight was noted. At 12.5 ppM, 8 of 9 rats survived. One died with above pathology at 213 days. Body weights were 20% less than normal. Increased respiratory rate of 60 per min as opposed to 40 for control was noted. Emphysema occurred in terms of voluminous lungs but with no inflammation. Hyperplasia, accumulation of mucus and macrophages may obstruct terminal bronchioles.
- OSTI ID:
- 6288679
- Journal Information:
- Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 8; ISSN AEHLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
BRONCHI
CHALCOGENIDES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EDEMA
EMPHYSEMA
HYPERTROPHY
MAMMALS
MORTALITY
MUCOUS MEMBRANES
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SYMPTOMS
VERTEBRATES