Pathogenesis of the nitrogen dioxide-induced lesion in the rat lung: a review and presentation of new observations

Journal Article · Sun Dec 31 23:00:00 EST 1967 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:6288749

Freeman, G; Crane, S C; Stephens, R J; Furiosi, N J

Review of previous work primarily is presented. Concentrations of 10 to 25 ppM NO/sub 2/ was non-edemagenic and non-necrotizing in rats but did result in increased weight of voluminous, air-retaining lungs. Increase in lung weight was due to hypertrophy of respiratory epithelium in alveoli and terminal bronchioles, and not to excessive fluid or blood. A concentration 2 +- 1 ppM for a lifetime did not produce emphysema but reduced bronchiolar cilia, inhibited normal exfoliation and blebbing of epithelial cells, and produced cytoplasmic, crystalloid inclusions of uncertain nature.

• OSTI ID: 6288749
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 98; ISSN ARRDA
• Country of Publication: United States
• Language: English

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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRONCHI
CHALCOGENIDES
DISEASES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
EMPHYSEMA
EPITHELIUM
LUNGS
MAMMALS
MORPHOLOGICAL CHANGES
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
POLLUTION
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
REVIEWS
RODENTS
TISSUES
VERTEBRATES