Effect of dietary lead and calcium on tissue lead accumulation and depletion in sheep

Conference · Mon Jun 01 04:00:00 EDT 1981 · Trace Subst. Environ. Health; (United States)

OSTI ID:6238059

Pearl, D S; Ammerman, C B; Henry, P R; Littell, R C

An experiment was conducted to study the effect of dietary lead and calcium on tissue accumulation and depletion of Pb in sheep. In a feeding trial 40 wether lambs, 56 kg initially, were assigned randomly to 2 dietary treatments: .25% Ca + 1000 ppM Pb or .50% Ca + 1000 ppM Pb. Supplemental Ca was supplied as reagent grade calcium carbonate and Pb as reagent grade lead acetate. The experiment was divided chronologically into 2 phases of 75 and 180 days, respectively. During the first phase, diets contained 1000 ppM supplemental Pb and during the second phase, 3 ppM Pb. The 2 levels of Ca were fed throughout both phases. Two sheep from each treatment group were euthanized at intervals during each period and selected tissues removed for mineral analyses. Lead accumulation and depletion curves were generated in kidney, liver and bone. Lead increased in all tissues during the accumulation period and decreased during the depletion period. The mean liver Pb concentration for sheep killed at the beginning of the experiment was 1.1 ppM (dry matter basis) and it increased to 13.5 ppM in the livers of sheep euthanized at the end of 75 days and decreased to 3.0 ppM after being depleted for 180 days. Tissue Pb returned to initial values in kidney but did not in liver or bone by the ened of the 180 day depletion period. There was no effect of increased dietary Ca on the accumulation or depletion of tissue Pb except for liver where increased dietary Ca reduced (p < .05) the amount of Pb deposited.

• Research Organization: Univ. of Florida, Gainesville
• OSTI ID: 6238059
• Report Number(s): CONF-8106251-
• Conference Information: Journal Name: Trace Subst. Environ. Health; (United States) Journal Volume: 15
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
CALCIUM
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
ELEMENTS
GLANDS
KIDNEYS
LEAD
LIVER
MAMMALS
METABOLISM
METALS
ORGANS
RUMINANTS
SENSITIVITY
SHEEP
SKELETON
TISSUE DISTRIBUTION
VERTEBRATES