Interactions of dietary calcium with toxic levels of lead and zinc in pigs

Journal Article · Wed Jan 01 04:00:00 EST 1975 · J. Nutr.; (United States)

OSTI ID:6049334

Hsu, F A; Krook, L; Pond, W G; Duncan, J R

Twenty-four weanling Yorkshire pigs were used in a 2 x 2 x 2 factorial arrangement of treatments to determine their response to high levels of dietary lead (Pb) (1000 ppm) and zinc (Zn) (4000 ppm) (as lead acetate and zinc oxide), to investigate the influence of high dietary calcium (Ca) (1.1%) on the biochemical and morphological manifestations of Pb and Zn toxicity, and to determine the effect of excess Zn on Pb toxicity. Clinical signs of Pb toxicity included behavioral changes, lameness, and anorexia. Pb content of blood, soft tissues, and bone was increased markedly by 1000 ppm Pb in the diet during the 13-week experiment. Zn and Pb fed together, as compared with Pb alone, tended to increase Pb levels in blood, soft tissues, and bone and to enhance the toxic effects of Pb as shown by reduced weight gains, severe clinical signs, and pathological changes. High Ca reduced blood and bone Zn and Pb concentrations. The results indicate that high dietary Ca has a protective effect against the adverse effects of diet Pb and Zn, and that Zn aggravates Pb toxicity in growing pigs.

• Research Organization: Cornell Univ., Ithaca, NY
• OSTI ID: 6049334
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 105:1; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL EFFECTS
BUILDUP
CALCIUM
COMPARATIVE EVALUATIONS
DOMESTIC ANIMALS
ELEMENTS
LEAD
MAMMALS
METALS
SWINE
TOXICITY
UPTAKE
VARIATIONS
VERTEBRATES
ZINC