Dietary lead and metabolism of /sup 210/Pb and stable Pb in sheep

Journal Article · Wed Dec 31 23:00:00 EST 1975 · J. Anim. Sci.; (United States)

OSTI ID:6428313

Fick, K R; Ammerman, C B; Roessler, C E; Feaster, J P; Hansard, II, S L

Twelve Florida native wethers averaging 37 kg initially were used in a 2 x 2 factorial arrangement of treatments to study the absorption, excretion and retention of radioactive and stable lead as influenced by dietary intake of lead and pathway of isotope administration. The animals were fed a natural diet containing 3.1 ppm lead and received either 50 or 1000 ppm dietary lead as lead acetate. A 107-day preliminary feeding period was followed by the administration of 830 ..mu..Ci of /sup 210/Pb orally or 270 ..mu..Ci of /sup 210/Pb intravenously. Fecal and urinary collections were made for 8 days. Blood samples were obtained by venipuncture at periodic intervals up to 198 hr following dosing, after which all sheep were sacrificed and selected tissues removed for analysis. Within 8 days, 68.5 and .06% of the total /sup 210/Pb oral dose appeared in the feces and urine, respectively. Animals administered /sup 210/Pb intravenously excreted 12.5% of the total /sup 210/Pb injected in the feces and 12.0% in the urine. Percent injected dose of /sup 210/Pb in whole blood decreased rapidly to less than 10% at 96 hr following dosing. Radioactivity in the blood of sheep given the /sup 210/Pb orally was never detected in more than trace quantities. Low dietary lead and intravenous administration of /sup 210/Pb resulted in the greatest tissue retention of /sup 210/Pb when expressed as percent of dose per kilogram of dry tissue. Tissue levels of stable lead were higher in sheep fed the higher level of dietary lead.

• Research Organization: Univ. of Florida, Gainesville
• OSTI ID: 6428313
• Journal Information: J. Anim. Sci.; (United States), Journal Name: J. Anim. Sci.; (United States) Vol. 43:1; ISSN JANSA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY FLUIDS
CLEARANCE
DIET
DISTRIBUTION
DOMESTIC ANIMALS
ELEMENTS
EVEN-EVEN NUCLEI
EXCRETION
FECES
HEAVY NUCLEI
ISOTOPES
LEAD
LEAD 210
LEAD ISOTOPES
MAMMALS
MATERIALS
METABOLISM
METALS
NUCLEI
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
RUMINANTS
SHEEP
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES