Biological fate of a single administration of $sup 191$Pt in rats following different routes of exposure

Journal Article · Tue Apr 01 04:00:00 EDT 1975 · Environ. Res., v. 9, no. 2, pp. 152-158

OSTI ID:4088440

Moore, W Jr; Hysell, D; Crocker, W; Stara, J

The retention, tissue distribution, and excretion of $sup 191$Pt in adult rats was determined following oral, intravenous (IV), and intratracheal administration. The highest retention was obtained following IV dosing, and lowest retention (less than 0.5 percent) occurred after oral dosing. Tissues containing the highest concentrations of $sup 191$Pt following IV administration were the kidney, adrenal, spleen, and liver. Following a single oral dose, almost all of the $sup 191$Pt was excreted in the feces due to nonabsorption, whereas after IV dosing, similar quantities were excreted in both the urine and feces. Following IV dosing of pregnant rats, $sup 191$Pt was found in all the fetuses; however, the amount was small. (auth)

• Research Organization: Environmental Protection Agency, Cincinnati, OH
• NSA Number: NSA-33-020577
• OSTI ID: 4088440
• Journal Information: Environ. Res., v. 9, no. 2, pp. 152-158, Journal Name: Environ. Res., v. 9, no. 2, pp. 152-158; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

*PLATINUM 191-- UPTAKE
*RATS-- RADIONUCLIDE KINETICS
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
COMPARATIVE EVALUATIONS
FETUSES
INTRATRACHEAL ADMINISTRATION
INTRAVENOUS INJECTION
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
ORAL ADMINISTRATION
PREGNANCY