THE METABOLISM OF INDIUM AFTER ADMINISTRATION OF A SINGLE DOSE TO THE RAT BY INTRATRACHEAL, SUBCUTANEOUS, INTRAMUSCULAR AND ORAL INJECTION
Distribution and excretion of indium after four routes of administration were studied by counting the activity of tissues from rats injected with tracer amounts of indium114m. In 4 days over half the administered dose was absorbed from the injection sites in all but the oral route where absorption was in the order of O.5% of the administered dose. A general distribution of the isotope was seen after all routes studied, with kidney, spleen, liver, and salivary glands containing higher concentrations. Pelt, skeleton, and muscle contained the largest absolute amounts of indium, and of these three skeleton had the highest concentration. Excretion of indium, with the exception of the oral route, was essentially independent of route of administration, occurring with an early rapid phase and a long slow phase which approximated a single exponential after about 20 days, At 30 days after administration 33 to 40% of the administered dose had been eliminated from the body in urine and feces. Urinary exeretion data after all but the oral route were so similar that they were treated statistically as one population and may form the basis fur a reliable bio- assay method utilizing analysis of daily urine samples. (auth)
- Research Organization:
- Univ. of Rochester, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-008491
- OSTI ID:
- 4097988
- Journal Information:
- Health Physics (England), Journal Name: Health Physics (England) Vol. Vol: 4; ISSN HLTPA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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