DISTRIBUTION AND EXCRETION OF INDIUM-114m AFTER MULTIPLE INTRAMUSCULAR INJECTION TO THE RAT

Technical Report · Tue Jun 23 04:00:00 EDT 1959

OSTI ID:4220617

Smith, G A; Thomas, R G; Scott, J K

Distribution and excretion of indium-114m were studied after multiple intramuscular injection in rats over a period of one year. It was found to distribute throughout the body concentrating somewhat in glandular tissues, spleen, and kidney in a pattern similar to that seen after single injections. Spleen and salivary glands, however, increased in relative indium concentration after multiple administration. After it had been absorbed from the injection site, the indium left the body burden at a rate that was approximately exponential with an effective half-time of 38.3 days. the same kinetics were followed independently of the number of doses given. Excretion occurred in both feces and urine in two phases, each of which could be described by some exponential function. Maximum permissible concentrations of indium-114m were calculated using whole body, spleen, and kidney as pDssible critical organs. The values calculated on the basis of these data were compared with existing values as reported in NBS Handbook 69. Sarcomas were observed in several animals at the injection sites having two doses of indium. Microscopic examinations of these tissues were made, and further experiments to show whether these tumors were indium or radiation induced are discussed. (auth)

• Research Organization: Rochester, N.Y. Univ. Atomic Energy Project
• NSA Number: NSA-13-019783
• OSTI ID: 4220617
• Report Number(s): UR-554
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
BONES
CARCINOGENESIS
CONTROL
DISTRIBUTION
GLANDS
HALF-LIFE
INDIUM 114
KIDNEYS
METABOLISM
MICROSCOPY
QUANTITY RATIO
RATS
SALIVARY GLANDS
SARCOMAS
SPLEEN
TUMORS
URINE