Studies on the distribution of radioisotopes by whole body autoradiography. 30. The fate of $sup 14$C-HOPA in rats and mice

Journal Article · Fri Mar 31 23:00:00 EST 1972 · Bitamin, v. 45, no. 4, pp. 193-200

OSTI ID:4387626

Nakamura, S; Takahashi, T; Sato, Y

The absorption, distribution, excretion, and metabolism of /sup 14/CHOPA were studied in rats and mice following oral administration. When /sup 14/C-HOPA was administered orally to rat, the radioactivity was absorbed rapidly from the digestive tract, the half-life for absorption being 110 minutes. Thirty minutes after oral administration of /sup 14/C-HOPA in mice, the concentration of the radioactivity was conspicuous in the liver and kidney, and moderate in the testis, muscle and spleen, and that in the brain was extremely low. The autoradiographic distribution pattern of /sup 14/C-HOPA was similar to that of intravenous route. The highest concentration of the radioactivity in the brain of rats reached 3 hours after oral administration, and the amount of HOPA was 1.4 mu g per gram of the wet weight. Sixty-five percent of the radioactivity of / sup 14/C-HOPA was excreted in urine of rats within 48 hours and 28.5% in feces. Ninety-eight percent of the urinary radioactivity accounted for unchanged /sup 14/ C-HOPA and 2.0% accounted for an unknown metabolite. (auth)

• Research Organization: Tanabe Seiyaku Co. Ltd., Toda, Japan
• NSA Number: NSA-29-016069
• OSTI ID: 4387626
• Journal Information: Bitamin, v. 45, no. 4, pp. 193-200, Journal Name: Bitamin, v. 45, no. 4, pp. 193-200; ISSN BTMNA
• Country of Publication: Japan
• Language: Japanese

Related Subjects

*BRAIN-- RADIOACTIVITY
*CARBON 14-- TISSUE DISTRIBUTION
*KIDNEYS-- RADIOACTIVITY
*LIVER-- RADIOACTIVITY
*MUSCLES-- RADIOACTIVITY
*PANTOTHENIC ACID-- METABOLISM
*TESTES-- RADIOACTIVITY
ABSORPTION
GASTROINTESTINAL TRACT
LABELLED COMPOUNDS
MICE
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
ORAL ADMINISTRATION
RATS