Disposition of 9-aminoacridine in rats dosed orally or intravenously and in monkeys dosed topically

Journal Article · Tue Jan 01 04:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530705· OSTI ID:6234851

el Dareer, S M; Kalin, J R; Tillery, K F; Hill, D L

Following administration of ( UC)-labeled 9-aminoacridine (( UC)9AA) hydrochloride either orally or intravenously to rats, the excretion of radioactivity was similar, with 20-26% of the dose appearing in the urine and 57-68% in the feces. The pattern of tissue distribution was also similar for the two routes. This information suggests that absorption of the oral doses was extensive and that, for both routes of administration, biliary excretion accounted for most of the radioactivity in the feces. Biliary excretion of radioactivity derived from ( UC)9AA was confirmed in an experiment involving rats with inserted biliary cannulas. For these rats, 49.5% of the dose administered appeared in the bile in 4 h. The major urinary and biliary metabolite of ( UC)9AA of rats was identified as an O-beta-glucuronide of hydroxylated 9AA. Absorption of 9AA through the skin could not be conclusively demonstrated. For monkeys dosed topically with ( UC)9AA, only small amounts of radioactivity appeared in the urine and various tissues in 24 h.

• Research Organization: Southern Research Institute, Birmingham, AL
• OSTI ID: 6234851
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACRIDINES
ANIMALS
AROMATICS
AZAARENES
AZINES
BILE
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBON 14 COMPOUNDS
CHROMATOGRAPHY
CLEARANCE
DISTRIBUTION
EXCRETION
HETEROCYCLIC COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MATERIALS
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
RATS
RODENTS
SEPARATION PROCESSES
TISSUE DISTRIBUTION
VERTEBRATES