Disposition of 2-(2-quinolyl)-1,3-indandione (D. C. yellow number11) in rats dosed orally or intravenously
The disposition of 2-(2-quinolyl)-1,3-indandione (D. C. yellow number11, DCY) in male Fischer rats dosed intravenously or by feeding was determined. For rats given (/sup 14/C)DCY in the feed (0.00044-0.41% of the diet), recovery of radioactivity during the 24-h dosing period and the 72-h period thereafter ranged from 89.1 to 93.9% for feces and from 4.98 to 6.25 for urine. Tissues contained only trace amounts. Following intravenous dosing with (/sup 14/C)DCY (0.93 mg/kg), radioactivity distributed readily into most tissues; maximum amounts were present at 5 min, the earliest time of assay. Maximum amounts of radioactivity in fat, skin, and gut tissue, however, were present at 30 min after dosing. These three tissues also had relatively long alpha phases for the elimination of radioactivity. In 24 h after intravenous dosing, rats excreted 81.1% of the dose in the feces and 16.0% of the dose in the urine. For rats fitted with biliary cannulas, 54.5% of the dose, all of which was metabolites of (/sup 14/C)DCY, was recovered in the bile in 4 h. Associated with the rapid and extensive biliary excretion of metabolites of intravenously administered (/sup 14/C)DCY was the appearance of large amounts of radioactivity in the feces and also, at intermediate time points, in the liver, gut contents, and gut tissue. In conclusion, rats rapidly distribute, metabolize, and excrete (/sup 14/C)DCY.
- Research Organization:
- Southern Research Institute, Birmingham, AL (USA)
- OSTI ID:
- 6939153
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 23:3; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AROMATICS
AZAARENES
AZINES
CARBON 14 COMPOUNDS
DISTRIBUTION
DYES
HETEROCYCLIC COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
METABOLITES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
QUINOLINES
RATS
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES