The elimination, distribution, and metabolism of /sup 14/C-toxaphene in the pregnant rat

Journal Article · Fri Jan 01 04:00:00 EST 1982 · J. Environ. Sci. Health, Part B; (United States)

DOI:https://doi.org/10.1080/03601238209372347· OSTI ID:5852582

Pollock, G A; Hillstrand, R

Pregnant Sprague-Dawley rats were orally administered /sup 14/C-toxaphene in olive oil on day 15 of pregnancy and housed in glass metabolism cages. Urine, feces, and tissues were collected and assayed for radioactivity. The elimination was similar to that in virgin females with the majority of activity excreted in the feces (38.4%; five days) and less in the urine (23.7%; five days). The fetuses contained the lowest levels of radioactivity of all tissues tested (28 ppb; five days) and fat contained the highest levels (7476 ppb; five days). A comparison of the activity in the fetuses with that in the dam's fat showed slight differences, indicating the presence of more polar compounds (perhaps metabolites).

• Research Organization: WOI Regional Program in Veterinary Medical Education, Veterinary Medicine, University of Idaho, Moscow
• OSTI ID: 5852582
• Journal Information: J. Environ. Sci. Health, Part B; (United States), Journal Name: J. Environ. Sci. Health, Part B; (United States) Vol. 17:6; ISSN JPFCD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CLEARANCE
DISTRIBUTION
EXCRETION
FECES
FETUSES
INSECTICIDES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
PESTICIDES
RATS
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES