Radiographic analysis of the effect of dietary fibers on rat colonic transit time
- Texas A M Univ., College Station (USA)
The effect of different fiber sources on colonic transit time was charted using serial radiographs. Sixty male Sprague-Dawley rats, 10 rats per group, were provided with either a fiber-free control diet or the control diet uniformly diluted to provide 8% dietary fiber from guar, pectin, cellulose, wheat bran, or oat bran. At surgery, radiopaque markers were inserted at defined distances in the mesentary closest to the large bowel. Three weeks postsurgery, the animals were intubated with 0.5 ml of a radiopaque marker, and radiographs were taken at 15-min intervals. Of the two poorly fermented fibers, cellulose was as slow as and wheat bran was faster than the fiber-free controls at five out of the six bowel segments measured. The fermentable fibers (pectin, guar, and oat bran) were fast through some bowel segments and slow through others. This study provides in vivo data on colonic transit time and shows that neither 24-h fecal weight nor total transit time is a good predictor of the rate of transit through particular gut segments.
- OSTI ID:
- 6228729
- Journal Information:
- American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 255:5; ISSN 0002-9513; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BLOOD SUBSTITUTES
CARBOHYDRATES
CELLULOSE
CEREALS
DIAGNOSTIC TECHNIQUES
DIET
DIGESTION
DIGESTIVE SYSTEM
DRUGS
DYNAMIC FUNCTION STUDIES
FIBERS
GASTROINTESTINAL TRACT
GRAMINEAE
HEMATOLOGIC AGENTS
LILIOPSIDA
MAGNOLIOPHYTA
MAMMALS
MEDICINE
NUCLEAR MEDICINE
OATS
ORGANIC COMPOUNDS
PECTINS
PLANTS
POLYSACCHARIDES
RADIOLOGY
RATS
RODENTS
SACCHARIDES
VERTEBRATES
WHEAT