Reduced thrombogenic characteristics of expanded polytetrafluoroethylene and polyurethane arterial grafts after heparin bonding

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Surgery; (United States)

OSTI ID:6221561

Esquivel, C O; Bjoerck, C G; Bergentz, S E; Bergqvist, D; Larsson, R; Carson, S N; Dougan, P; Nilsson, B

The effect of bonding of heparin, via a glutaraldehyde-stabilized ionic complex, on the early thrombogenicity of polyurethane (PU) and expanded polytetrafluoroethylene (PTFE) (Gore-tex) as well as covalent bonding of heparin on PTFE was studied in vivo. Grafts 6 cm long and 4 mm in diameter were placed in the carotid arteries of sheep and perfused for 4 hours at 25 ml/min in order to accelerate thrombus formation. The thrombogenicity was determined by calculation of the percent of the luminal surface free of thrombus and patency. In addition, 32P-labelled platelet accumulation was determined in some of the grafts. The stabilized ionic bonding of heparin significantly reduced the early thrombogenicity of PU but had little effect on PTFE grafts; but the thrombogenicity of the latter was markedly decreased following covalent bonding of heparin. A regional distribution of platelet accumulation was found with the distal anastomoses showing the highest platelet deposition. By choice of an appropriate method of heparinization, a significant reduction of the thrombogenicity of PU and PTFE grafts was achieved.

• Research Organization: Univ. of California, Davis
• OSTI ID: 6221561
• Journal Information: Surgery; (United States), Journal Name: Surgery; (United States) Vol. 95:1; ISSN SURGA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
ANTICOAGULANTS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CHEMICAL BONDS
DAYS LIVING RADIOISOTOPES
DISEASES
DOMESTIC ANIMALS
DRUGS
GRAFTS
HEMATOLOGIC AGENTS
HEPARIN
ISOTOPE APPLICATIONS
ISOTOPES
LABELLING
LIGHT NUCLEI
MAMMALS
MATERIALS
MUCOPOLYSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANIC SULFUR COMPOUNDS
ORGANS
PETROCHEMICALS
PETROLEUM PRODUCTS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PLASTICS
POLYAMIDES
POLYETHYLENES
POLYMERS
POLYOLEFINS
POLYSACCHARIDES
POLYURETHANES
RADIOISOTOPES
RUMINANTS
SACCHARIDES
SHEEP
SORPTIVE PROPERTIES
SURFACE PROPERTIES
SYNTHETIC MATERIALS
THROMBOSIS
TRACER TECHNIQUES
TRANSPLANTS
VASCULAR DISEASES
VERTEBRATES