Effects of caffeine on the expression of potentialy lethal and sublethal damage in. gamma. -irradiated cultured mammalian cells. [Human T-1 cells and Chinese hamster V79-79 cells]
Journal Article
·
· Radiat. Res.; (United States)
Caffeine was found to potentiate single-dose cobalt-60 ..gamma..-ray-induced lethality in human T-1 and Chinese hamster V79-79 cells when present at 2.0 and 2.5 mM for 21 to 48 hr after irradiation. In split-dose experiments, 2 mM caffeine apparently did not affect survival when present only for the 4 hr between doses. As 4 hr is sufficient time for these cells to complete sublethal damage repair, it is concluded that caffeine affects the expression of potentially lethal damage but not the expression of sublethal damage.
- Research Organization:
- The Pennsylvania State Univ., University Park
- OSTI ID:
- 6221288
- Journal Information:
- Radiat. Res.; (United States), Vol. 78:2
- Country of Publication:
- United States
- Language:
- English
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Mon Jun 01 00:00:00 EDT 1981
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
CAFFEINE
RADIOSENSITIVITY EFFECTS
FRACTIONATED IRRADIATION
RADIATION INJURIES
BIOLOGICAL REPAIR
ACUTE IRRADIATION
CELL CULTURES
CELL KILLING
COBALT 60
EXPERIMENTAL DATA
GAMMA RADIATION
GRAPHS
IN VITRO
MAMMALS
SURVIVAL TIME
ACUTE EXPOSURE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
COBALT ISOTOPES
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
INFORMATION
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
VERTEBRATES
XANTHINES
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
CAFFEINE
RADIOSENSITIVITY EFFECTS
FRACTIONATED IRRADIATION
RADIATION INJURIES
BIOLOGICAL REPAIR
ACUTE IRRADIATION
CELL CULTURES
CELL KILLING
COBALT 60
EXPERIMENTAL DATA
GAMMA RADIATION
GRAPHS
IN VITRO
MAMMALS
SURVIVAL TIME
ACUTE EXPOSURE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
COBALT ISOTOPES
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
INFORMATION
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
VERTEBRATES
XANTHINES
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)