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Effects of caffeine on the expression of potentialy lethal and sublethal damage in. gamma. -irradiated cultured mammalian cells. [Human T-1 cells and Chinese hamster V79-79 cells]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575047· OSTI ID:6221288
Caffeine was found to potentiate single-dose cobalt-60 ..gamma..-ray-induced lethality in human T-1 and Chinese hamster V79-79 cells when present at 2.0 and 2.5 mM for 21 to 48 hr after irradiation. In split-dose experiments, 2 mM caffeine apparently did not affect survival when present only for the 4 hr between doses. As 4 hr is sufficient time for these cells to complete sublethal damage repair, it is concluded that caffeine affects the expression of potentially lethal damage but not the expression of sublethal damage.
Research Organization:
The Pennsylvania State Univ., University Park
OSTI ID:
6221288
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 78:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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