New derivation, from split-dose data, of the complete survival curve for clonogenic normal cells in vivo. [X rays; gastirc and jejunal crypt cells; spermatocytes; bone marrow cells (FU); mice]
A method is described for completing the shoulder region of survival curves for clonogenic cells that are grouped into multicellular structures, for which the multiplicity produces a threshold region at low single doses, which masks the shoulder of the single-cell survival curve. The method uses split-dose irradiation, with a time interval considered sufficient for restitution of the original dose-response relationship. First, large equal split doses are used to provide a surviving fraction for the second dose (assumed equal to that for the first), and survival values for higher single doses are calculated with reference to the latter. Second, survival levels for lower single doses are deduced from the additional effect of small doses over their large-dose counterparts. New data are presented and analyzed for mouse jejunal crypts, and published data for gastric crypts and spermatogonia (which regenerate tubules) are similarly analyzed. A close similarity is seen between the response of gastriccryptogenic cells and spermatogenic cells, with jejunal cryptogenic cells being slightly more sensitive.
- Research Organization:
- Christie Hospital and Holt Radium Inst., Manchester, England
- OSTI ID:
- 6220663
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 78:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW CELLS
CESIUM 137
CESIUM ISOTOPES
CFU
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
CRYPT CELLS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GAMETES
GAMMA RADIATION
GASTROINTESTINAL TRACT
GERM CELLS
INFORMATION
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MICE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RODENTS
SMALL INTESTINE
SOMATIC CELLS
SPERMATOGONIA
STOMACH
SURVIVAL CURVES
TEMPORAL DOSE DISTRIBUTIONS
THEORETICAL DATA
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES