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The response of murine intestinal crypts to short-range promethium-147 beta irradiation: Deductions concerning clonogenic cell numbers and positions

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3577450· OSTI ID:5715312
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An exteriorized loop of mouse intestine was exposed to /sup 147/Pm low-energy electrons, where the dose rate decreased by a factor of 5 from the base of the crypt to the top of the proliferative zone. A crypt survival curve was obtained, expressed in terms of exposure time. The shape of the curve was interpreted in terms of survival parameters for colony-forming cells (clonogens) derived using /sup 137/Cs gamma rays and the depth-dose curve measured for /sup 147/Pm electrons. It is concluded that the shape of the crypt survival curve using /sup 147/Pm electrons is inconsistent with the notion of either the presence of a large number of clonogens or a small number near the top of the proliferative zone. A computer fitting procedure showed that the best agreement between predicted and observed curves was achieved with 2.7 +/- 0.5 clonogens at cell position 5.6 +/- 0.6, in the putative stem-cell zone.

Research Organization:
Paterson Institute for Cancer Research, Manchester (England)
OSTI ID:
5715312
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 118:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA PARTICLES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL PROLIFERATION
CHARGED PARTICLES
COLONY FORMATION
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELECTRONS
ELEMENTARY PARTICLES
FERMIONS
GASTROINTESTINAL TRACT
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPES
LEPTONS
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROMETHIUM 147
PROMETHIUM ISOTOPES
RADIATION EFFECTS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RODENTS
SMALL INTESTINE
SURVIVAL CURVES
VERTEBRATES
YEARS LIVING RADIOISOTOPES