Single-dose-response curves of murine gastrointestinal crypt stem cells. [Gamma radiation]

Journal Article · Fri Dec 31 23:00:00 EST 1976 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574517· OSTI ID:7227739

Masuda, K; Withers, H R; Mason, K A; Chen, K Y

Dose-response curves for the reproductive capacity of crypt stem cells of murine colonic, jejunal, and gastric mucosae exposed in situ to multifractionated gamma ray exposures were analyzed and single-dose-survival curves of these cells were constructed. The following conclusions were drawn: (1) The single-dose-response curves bend downward over a dose range of approximately 200 to 1500 rad; (2) cell death seems to be due to nonrepairable damage at doses less than 250 rad for colon, and 220 rad for jejunum; (3) there are 21, 110, and 140 stem cells per crypt of gastric, colonic, and jejunal mucosa, respectively; and (4) jejunal stem cells are the most radiosensitive and gastric mucosal stem cells are the most resistant.

• Research Organization: Univ. of Texas, Houston
• OSTI ID: 7227739
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 69:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL PROLIFERATION
CRYPT CELLS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
IONIZING RADIATIONS
MAMMALS
MICE
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
STEM CELLS
VERTEBRATES