Single dose response curves of normal cells in situ
Analysis of data on the response of normal tissues (skin, lung, spinal cord, intestine, testis) to single and multifractionated irradiation schedules revealed the characteristics of the single dose survival curves of target cells responsible for skin, lung, and spinal cord reactions, and of stem cells of colonic, jejunal, gastric mucosae, and testis exposed in situ to relatively low doses of x- or gamma-rays. The single dose survival curves of these cells seem to be complex (unlike those of cells studied in vitro), that is, simply exponential in the initial portion up to approximately 250 rads, and downward-bending thereafter in a curve which includes one or two linear portions on a semilogarithmic scale.
- Research Organization:
- M.D. Anderson Hospital and Tumor Inst., Houston, TX
- OSTI ID:
- 7227741
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 122:1; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CULTURES
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
GONADS
INTESTINES
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
LUNGS
MALE GENITALS
NERVOUS SYSTEM
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SKIN
SPINAL CORD
SURVIVAL CURVES
TESTES
X RADIATION