Dose-survival characteristics of mouse jejunal crypt cells

Journal Article · Sat Oct 31 23:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90091-2· OSTI ID:5794769

Thames, H D ^[1]; Withers, R; Mason, K A; Reid, B O

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1. Univ. of Texas System Cancer Center, Houston

The survival of mouse jejunal crypt cells after multiple doses of /sup 60/Co ..gamma..-rays has been measured with the microcolony technique. Fractionation protocols were designed with common dose fractions in regimens with different fraction numbers. An average number of 152 clonogens per crypt was estimated from the experiments. The survival curve has a broad shoulder, remaining near-exponential over the initial dose range 0 to 300 rad, with initial slop /sub 1/D/sub 0/=357 rad. It is not possible to distinguish between the linear-quadratic (LQ) and two-component (TC) survival models on the basis of the result of these experiments.

• OSTI ID: 5794769
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:11; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
CRYPT CELLS
DOSES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
SURVIVAL TIME
VERTEBRATES
YEARS LIVING RADIOISOTOPES