Chemical basis for photomutagenicity in synthetic fuels traced

Journal Article · Mon Dec 01 04:00:00 EST 1986 · Pace Synth. Fuels Rep.; (United States)

OSTI ID:6211581

The high incidence of skin cancers which was seen in early shale oil and coal conversion workers points to a problem which must be addressed by the developing synthetic fuels industries. The Kentucky Energy Cabinet has been funding studies to aid in developing inexpensive and rapid tests that can predict tumor initiating, tumor promoting, cocarcinogenic and anticarcinogenic activities in synthetic fuel materials. Some preliminary results from this work are reported here. Although a relatively limited number of samples were tested, the data suggest that high boiling point components in the PAH-enriched fraction are the determinant chemical photomutagen in synthetic fuels. In summary, of 11 samples that were tested for carcinogenicity, photomutagenicity and enzyme-mediated mutagenicity, in 7 cases there was agreement between all three assays and in 4 cases the photomutagenicity data was in better qualitative agreement with carcinogenicity than were the mutagenicity data obtained using enzyme activation. The strong agreement between photomutagenicity and carcinogenicity among the synfuel materials could be coincidental. However, the agreement is sufficiently extensive to consider possible fundamental underlying relationships. 3 figures, 1 table.

• OSTI ID: 6211581
• Journal Information: Pace Synth. Fuels Rep.; (United States), Journal Name: Pace Synth. Fuels Rep.; (United States) Vol. 23:4; ISSN PSFRD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
CARCINOGENESIS
COAL LIQUIDS
DATA
ENERGY SOURCES
FLUIDS
FOSSIL FUELS
FUELS
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
INFORMATION
LIQUIDS
MATERIALS TESTING
MINERAL OILS
MUTAGENESIS
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
SHALE OIL
SYNTHETIC FUELS
TESTING
TOXICITY