Chemical basis for photomutagenicity in synthetic fuels

Conference · Tue Apr 01 04:00:00 EST 1986 · Am. Chem. Soc., Div. Gas Fuel Chem., Prepr.; (United States)

OSTI ID:5517617

Selby, C P; Calkins, J; Enoch, H G; Wright, C W; Wilson, B W

Photomutagens (chemicals that enhance the mutagenicity of near UV-visible radiation) have been detected in a variety of experimental coal- and oil shale-derived synthetic fuels using S.typhimurium strain TA98 and fluorescent light. In this study, photomutagenic activity was measured among synfuel samples that included crude and hydrotreated shale oil, coal liquid distillation fractions, and chemical class fractions of coal and shale oils. Photomutagenic activity was found to increase with increasing boiling point and was concentrated in fractions enriched in neutral polycyclic aromatic hydrocarbons (PAH). These results point to high molecular weight neutral PAH constituents as important photomutagenic components among the samples tested. The photomutagenic activities of the materials tested correlate well with the previously reported tumorigenic activities of the same samples on mouse skin but correlate poorly with the previously reported mutagenic activities in the conventional Salmonella/mammalian-microsome mutagenicity test in which neutral PAH fractions were inactive.

• Research Organization: Dept. of Radiation Medicine and Graduate Center for Toxicology, Univ. of Kentucky, Lexington, KY
• OSTI ID: 5517617
• Report Number(s): CONF-860425-
• Conference Information: Journal Name: Am. Chem. Soc., Div. Gas Fuel Chem., Prepr.; (United States) Journal Volume: 31:2
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000* -- Coal
Lignite
& Peat-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BACTERIA
BOILING POINTS
CHEMICAL REACTIONS
COAL LIQUIDS
CORRELATIONS
DISTILLATES
ELECTROMAGNETIC RADIATION
ENERGY SOURCES
FLUIDS
FLUORESCENT LAMPS
FOSSIL FUELS
FUELS
HYDROCARBONS
HYDROGENATION
LIGHT BULBS
LIQUIDS
MAMMALS
MICE
MICROORGANISMS
MINERAL OILS
MOLECULAR WEIGHT
MUTAGENESIS
MUTAGENS
NEAR ULTRAVIOLET RADIATION
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PHYSICAL PROPERTIES
POLYCYCLIC AROMATIC HYDROCARBONS
RADIATIONS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SHALE OIL
SYNTHETIC FUELS
THERMODYNAMIC PROPERTIES
TRANSITION TEMPERATURE
ULTRAVIOLET RADIATION
VERTEBRATES
VISIBLE RADIATION