Effect of hydrotreatment on the photomutagenicity of shale oil

Journal Article · Sat Feb 01 04:00:00 EST 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80004-4· OSTI ID:5729885

Selby, C P; Calkins, J; Enoch, H G

Dimethyl sulfoxide extracts of a parent crude and a hydrotreated Paraho shale oil were tested in Salmonella to detect the presence of direct acting mutagens, promutagens, which are converted by liver enzymes to direct acting mutagens, and photomutagens, which photosensitize Salmonella to mutation by fluorescent light. Direct acting mutagens were not detected in extracts of either shale oil. Both photomutagens and promutagens were detected in the parent crude, but only photomutagens were detected in the hydrotreated material. These results suggest that the photomutagens and promutagens were effected differently by hydrotreatment and that the two types of mutagens are to some degree different chemical entities. Both the crude and hydrotreated shale oils are reported to be carcinogenic in mouse skin, and our results of photomutation testing more closely parallel the carcinogenicity of the shale oils than do our results of testing with enzymatic activation.

• Research Organization: Univ. of Kentucky, Lexington
• OSTI ID: 5729885
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BODY
CELL CONSTITUENTS
CHEMICAL REACTIONS
ENERGY SOURCES
FLUORESCENCE
FOSSIL FUELS
FUELS
IN VITRO
LUMINESCENCE
MAMMALS
METABOLIC ACTIVATION
MICE
MICROORGANISMS
MICROSOMES
MINERAL OILS
MUTAGENS
OILS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
OTHER ORGANIC COMPOUNDS
PHOTOCHEMICAL REACTIONS
PROCESSING
REFINING
RODENTS
SALMONELLA
SHALE OIL
SKIN
TOXICITY
VERTEBRATES