Chemical basis for photomutagenicity in synthetic fuels

Conference · Sun Dec 01 04:00:00 EST 1985

OSTI ID:5736813

Selby, C P; Calkins, J; Enoch, H G; Wright, C W; Wilson, B W

Photomutagens (chemicals that enhance the mutagenicity of near uv-visible radiation) have been detected in a variety of experimental coal- and oil shale-derived synthetic fuels using S. typhimurium strain TA98 and fluorescent light. In this study, photomutagenic activity was measured among synfuel samples that included crude and hydrotreated shale oil, coal oil distillation fractions, and chemical class fractions of coal and shale oils. Photomutagenic activity was found to increase with increasing boiling point and was cencentrated in fractions enriched in neutral polycyclic aromatic hydrocarbons (PAH). These results point to high molecular weight neutral PAH constitutents as important photomutagenic components among the samples tested. The photomutagenic activities of the materials tested correlate well with the previously reported tumorigenic activities of the same samples on mouse skin but correlate poorly with the previously reported mutagenic activities in the conventional Salmonella/mammalian-microsome mutagenicity test in which neutral PAH fractions were inactive.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA); Kentucky Univ., Lexington (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5736813
• Report Number(s): PNL-SA-13632; CONF-860425-28; ON: DE86011132
• Country of Publication: United States
• Language: English

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