Late effects of unilateral radiation on the mouse kidney. [X ray]

Journal Article · Wed Nov 01 04:00:00 EST 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574791· OSTI ID:6202773

Jordan, S W; Yuhas, J M; Key, C R

A system is described for quantitative assessment of renal radiation damage in intact animals. Mice received 1000, 2000, 3000, or 6000 rad of single-dose x irradiation to the right kidney. Animals were sacrificed 6 months after irradiation, the ratio of left to right renal weight and the ratio of left to right renal weight showed reasonably good correlation with radiation dose, the latter comparison appearing to be more sensitive, due to the amplification of effect resulting from left renal hypertrophy and right renal atrophy. Mice receiving 1000 rad showed no significant histologic abnormalities, but evidenced definite tubular epithelial atrophic changes after doses of 2000 rad or greater.

• Research Organization: Univ. of New Mexico, Albuquerque
• OSTI ID: 6202773
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 76:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DELAYED RADIATION EFFECTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
HISTOLOGICAL TECHNIQUES
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
LOCAL IRRADIATION
MAMMALS
MICE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
VERTEBRATES
X RADIATION