Effect of photon irradiation on blood--brain barrier permeability to methotrexate in mice
Journal Article
·
· Cancer; (United States)
DOI:https://doi.org/10.1002/1097-0142(197709)40:3<1109::AID-CNCR2820400320>3.0.CO;2-5·
OSTI ID:5370125
- Univ. of Washington Hospital, Seattle
Methotrexate was administered by intraperitoneal injection (100 mg/kg) to unirradiated mice, and to mice receiving varying doses of cranial irradiation. The animals were sacrificed 24 hours after injection, and methotrexate assays were performed on brain tissue. No methotrexate was detected in the brains of the unirradiated animals. Detectable levels of methotrexate were present after 2000 rad cranial irradiation, but not after 500 rad, 1000 rad, or 1500 rad. The implications of these findings are discussed.
- OSTI ID:
- 5370125
- Journal Information:
- Cancer; (United States), Journal Name: Cancer; (United States) Vol. 40:3; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DIFFUSION
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELEMENTARY PARTICLES
MAMMALS
MASSLESS PARTICLES
METHOTREXATE
MICE
NERVOUS SYSTEM
ORGANS
PERMEABILITY
PHOTONS
RADIATION EFFECTS
RODENTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DIFFUSION
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELEMENTARY PARTICLES
MAMMALS
MASSLESS PARTICLES
METHOTREXATE
MICE
NERVOUS SYSTEM
ORGANS
PERMEABILITY
PHOTONS
RADIATION EFFECTS
RODENTS
VERTEBRATES