Effects of cyanide on selenium metabolism in rats
Adult male rats were given drinking water containing either 0 or 150 ppm cyanide for 2 weeks. They were then injected with 5 microCi /sup 75/Se-selenite, and excretion of radioactivity in urine and feces was determined. No difference in excretion of /sup 75/Se occurred during the rapid phase, but the cyanide-treated rats (T1/2 28 days) excreted significantly more /sup 75/Se in urine than control (T1/2 38 days) rats. Cyanide had no effect on excretion of /sup 75/Se in feces or on the distribution of /sup 75/Se in cytosolic proteins in liver, kidney, muscle or testes. In a second experiment weanling male rats were given water with either 0 or 150 ppm cyanide and were killed for glutathione peroxidase assay and selenium analysis in blood, kidney, liver, muscle and testes after 3, 6 or 9 weeks of treatment. Glutathione peroxidase activity and selenium concentrations were significantly reduced by cyanide in all tissues except testes.
- Research Organization:
- Oregon State Univ., Corvallis
- OSTI ID:
- 6199264
- Journal Information:
- J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 114:5; ISSN JONUA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CLEARANCE
CYANIDES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRINKING WATER
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
FECES
GLANDS
GONADS
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LIVER
MALE GENITALS
MAMMALS
MATERIALS
METABOLISM
MUSCLES
NUCLEI
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RATS
RODENTS
SELENITES
SELENIUM 75
SELENIUM COMPOUNDS
SELENIUM ISOTOPES
TESTES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES
WATER