Comparison of bone lesions in chronic cadmium intoxication and vitamin D deficiency

Journal Article · Wed Apr 01 04:00:00 EST 1981 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(81)90153-5· OSTI ID:6194463

Nogawa, K; Kobayashi, E; Konishi, F

Seventy female Wistar rats 90 to 100 g, were separated into eight groups according to three levels of vitamin D added to their diet (0, 1, and 5 IU/100 g of diet), two levels of cadmium (0 and 10 mg/100 g of diet), and the route - oral or subcutaneous - for administration of cadmium. After 500 days, the rats were killed and examined histologically and biochemically. Remarkable abnormalities were observed in the femurs and kidneys in cadmium-treated rats. Abnormal osteoplasic with formation of osteoid tissue were observed in both cadmium-treated, vitamin D-adequate rats, and vitamin D-deficient control rats. Renal lesions in the cadmium-treated rats were localized in tubules and the glomeruli were almost normal. The lowering of plasma calcium levels and the increase of urinary excretion of total protein, lysozyme, and calcium were observed in the cadmium-treated, vitamin D-adequate rats. Calcium concentrations in livers and femurs were decreased in both cadmium-treated rats and vitamin D-deficient control rats. The conclusion of the present work is that cadmium exposure over a long period could induce the same findings in bones and plasma as those of nutritional vitamin D deficiency.

• Research Organization: Kanazawa Univ., Japan
• OSTI ID: 6194463
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 24:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CADMIUM
CALCIUM
CHEMISTRY
CLEARANCE
COMPARATIVE EVALUATIONS
DIET
DIGESTIVE SYSTEM
ELEMENTS
EXCRETION
GLANDS
HISTOLOGY
KIDNEYS
LIVER
MAMMALS
METABOLISM
METALS
NUTRITIONAL DEFICIENCY
ORGANS
PATHOLOGICAL CHANGES
PUBLIC HEALTH
RATS
RENAL CLEARANCE
RODENTS
SENSITIVITY
SKELETON
TABLES
TIME DEPENDENCE
TOXICITY
VERTEBRATES
VITAMIN D
VITAMINS