Calcium and vitamin D metabolism in spontaneously hypertensive rats

Journal Article · Thu Oct 01 04:00:00 EDT 1987 · American Journal of Physiology; (USA)

OSTI ID:7266810

Hsu, Chen Hsing; Yang, Chweishiun; Patel, S R; Stevens, M G ^[1]

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1. Univ. of Michigan Medical School, Ann Arbor (USA)

The authors have studied the effect of dietary vitamin D restriction on serum levels of vitamin D metabolites, measured by radioreceptor assay and radioimmunoassay in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Both WKY and SHR were fed a vitamin D-deficient or a vitamin D-supplemented diet beginning at 4 wk of age. In vitamin D-supplemented animals, the serum 1,25-dihydroxycholecalciferol (1,25(OH){sub 2}D{sub 3}) concentration of WKY was similar to the level of SHR. Plasma calcium concentration was not different between WKY and SHR. In animals fed a vitamin D-deficient diet, the serum concentration of 1,25-(OH){sub 2}D{sub 3} of SHR was significantly lower than that of WKY. Plasma 25-hydroxycholecalciferol level was markedly decreased in both WKY and SHR. The SHR, but not the WKY, developed hypocalcemia. Despite hypocalcemia, fasting urinary Ca{sup 2+} excretion of SHR exceeded that of WKY. They conclude that the lower 1,25(OH){sub 2}D{sub 3} level in SHR fed a vitamin D-deficient diet may be due to a defect in the synthesis of 1,25(OH){sub 2}D{sub 3}. The low level of 1,25(OH){sub 2}D{sub 3} is associated with renal wasting of calcium and hypocalcemia in SHR.

• OSTI ID: 7266810
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:4; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOASSAY
CALCIUM COMPOUNDS
CARDIOVASCULAR DISEASES
CHOLECALCIFEROL
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HYPERTENSION
IMMUNOASSAY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIORECEPTOR ASSAY
RATS
RODENTS
SYMPTOMS
TRACER TECHNIQUES
UPTAKE
VASCULAR DISEASES
VERTEBRATES
VITAMIN D
VITAMINS