Mediation of calcium adaptation by 1,25-dihydroxycholecalciferol
Journal Article
·
· J. Nutr.; (United States)
OSTI ID:5775324
- Univ. of New Mexico, Albuquerque
Vitamin D-depleted chicks which were repleted with 25-hydroxycholecalciferol adapted to the feeding of a low or high calcium diet by respectively increasing or decreasing their rate of intestinal calcium absorption. The synthesis of 1,25-dihydroxycholecalciferol in chicks fed differing calcium diets correlated directly with intestinal calcium absorption activity, suggesting that the intestinal calcium adaptation response is medicated by the modulation of kidney 25-hydroxycholecalciferol-1-hydroxylase activity. This view was strongly supported by the demonstration that repletion of the chicks with 1,25-dihydroxycholecalciferol eliminated the ability of the chicks to adjust their rates of intestinal calcium absorption to dietary levels of calcium.
- OSTI ID:
- 5775324
- Journal Information:
- J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 107:11; ISSN JONUA
- Country of Publication:
- United States
- Language:
- English
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