Effect of cholecalciferol and 1,25-dihydroxycholecalciferol on the intestinal absorption of zinc in the chick

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · J. Nutr.; (United States)

OSTI ID:5724613

Koo, S I; Fullmer, C S; Wasserman, R H

The effect of cholecalciferol on the intestinal absorption of /sup 65/Zn was assessed in zinc-deficient and zinc-replete rachitic chicks, using the in situ ligated loop techniques. Cholecalciferol did not significantly affect /sup 65/Zn absorption in either group, although the synthesis of the intestinal calcium-binding protein (CaBP) in both groups was similar. In an analogous study, 1,25-dihydroxycholecalciferol increased /sup 47/Ca absorption and induced the synthesis of CaBP but exerted no effect on /sup 65/Zn absorption in zinc-deficient rachitic chicks. When fed a diet adequate in cholecalciferol, more CaBP was present in the intestine of the zinc-adequate group than in the zinc-deficient group, possibly due to the greater rate of growth and therefore the greater need for calcium by the former group. These results suggest that cholecalciferol and its most active metabolite do not directly affect zinc absorption and, by inference, that the vitamin D-dependent transport mechanism is not involved in zinc homeostasis, or in the interaction between calcium and zinc.

• Research Organization: Cornell Univ., Ithaca, NY
• DOE Contract Number: EY-76-S-02-2792
• OSTI ID: 5724613
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 110:9; ISSN JONUA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIRDS
CALCIUM 47
CALCIUM ISOTOPES
CHICKENS
CHOLECALCIFEROL
DAYS LIVING RADIOISOTOPES
DIET
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FOWL
HOMEOSTASIS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
METABOLITES
NUCLEI
RADIOISOTOPES
UPTAKE
VERTEBRATES
VITAMIN D
VITAMINS
ZINC 65
ZINC ISOTOPES