Effect of cholecalciferol and 1,25-dihydroxycholecalciferol on the intestinal absorption of zinc in the chick
The effect of cholecalciferol on the intestinal absorption of /sup 65/Zn was assessed in zinc-deficient and zinc-replete rachitic chicks, using the in situ ligated loop techniques. Cholecalciferol did not significantly affect /sup 65/Zn absorption in either group, although the synthesis of the intestinal calcium-binding protein (CaBP) in both groups was similar. In an analogous study, 1,25-dihydroxycholecalciferol increased /sup 47/Ca absorption and induced the synthesis of CaBP but exerted no effect on /sup 65/Zn absorption in zinc-deficient rachitic chicks. When fed a diet adequate in cholecalciferol, more CaBP was present in the intestine of the zinc-adequate group than in the zinc-deficient group, possibly due to the greater rate of growth and therefore the greater need for calcium by the former group. These results suggest that cholecalciferol and its most active metabolite do not directly affect zinc absorption and, by inference, that the vitamin D-dependent transport mechanism is not involved in zinc homeostasis, or in the interaction between calcium and zinc.
- Research Organization:
- Cornell Univ., Ithaca, NY
- DOE Contract Number:
- EY-76-S-02-2792
- OSTI ID:
- 5724613
- Journal Information:
- J. Nutr.; (United States), Vol. 110:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CALCIUM 47
HOMEOSTASIS
CHOLECALCIFEROL
BIOLOGICAL EFFECTS
ZINC 65
INTESTINAL ABSORPTION
BIOLOGICAL PATHWAYS
CHICKENS
DIET
ISOTOPE APPLICATIONS
METABOLITES
ABSORPTION
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIRDS
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FOWL
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
RADIOISOTOPES
UPTAKE
VERTEBRATES
VITAMIN D
VITAMINS
ZINC ISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550201 - Biochemistry- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques