Renal and skeletal lesions in experimental cadmium poisoning of rats. Histology and renal function

Journal Article · Sat Apr 01 04:00:00 EST 1978 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(78)90097-X· OSTI ID:6660115

Itokawa, Y; Nishino, K; Takashima, M; Nakata, T; Kaito, H; Okamoto, E; Daijo, K; Kawamura, J

The toxic effect of cadmium administration on the kidney and bone was studied in four groups of rats. Two groups were maintained on a diet sufficient in calcium and two on a diet deficient in calcium. One group receiving each diet was administered cadmium chloride, 0.02%, in the diet. Renal function tests revealed in rats administered cadmium: (1) increases in blood urea nitrogen and serum phosphorus levels; (2) decreases in the clearances of inulin, phosphorus, and calcium; and (3) an increase in the fractional excretion of calcium with an absence of a significant change in the tubular reabsorption of phosphorus. Histological analysis revealed that the renal lesion due to cadmium is located in the proximal tubules and histochemistry of the kidney provided evidence that the primary deposit site of cadmium is in the proximal tubular epithelium. In histological analysis of femurs, the appearance of ostoclasts was evident in the calcium deficient and cadmium-administered rats.

• Research Organization: Kyoto Univ.
• OSTI ID: 6660115
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 15:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
AMIDES
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CALCIUM
CARBOHYDRATES
CARBONIC ACID DERIVATIVES
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
CONTAMINATION
CRYOGENIC FLUIDS
DIET
ELEMENTS
FEMUR
FLUIDS
HALIDES
HALOGEN COMPOUNDS
HISTOLOGY
INULIN
KIDNEYS
MAMMALS
METALS
NITROGEN
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOSPHORUS
POISONING
POLYSACCHARIDES
RATS
RODENTS
SACCHARIDES
SKELETON
TUBULES
UREA
VERTEBRATES